Molecular Physiological Evidence for the Role of Na⁺-Cl^- Co-Transporter in Branchial Na⁺ Uptake in Freshwater Teleosts.

ABSTRACT: The gills are the major organ for Na⁺ uptake in teleosts. It was proposed that freshwater (FW) teleosts adopt Na⁺/H⁺ exchanger 3 (Nhe3) as the primary transporter for Na⁺ uptake and Na⁺-Cl^- co-transporter (Ncc) as the backup transporter. However, convincing molecular physiological evidence to support the role of Ncc in branchial Na⁺ uptake is still lacking due to the limitations of functional assays in the gills. Thus, this study aimed to reveal the role of branchial Ncc in Na⁺ uptake with an in vivo detection platform (scanning ion-selective electrode technique, SIET) that has been recently established in fish gills. First, we identified that Ncc2-expressing cells in zebrafish gills are a specific subt

SUBMITTER: Shih SW 

PROVIDER: S-EPMC10094795 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature