Mineral Metabolism in Children: Interrelation between Vitamin D and FGF23.

ABSTRACT: Fibroblast growth factor 23 (FGF23) was identified at the turn of the century as the long-sought circulating phosphatonin in human pathology. Since then, several clinical and experimental studies have investigated the metabolism of FGF23 and revealed its relevant pathogenic role in various diseases. Most of these studies have been performed in adult individuals. However, the mineral metabolism of the child is, to a large extent, different from that of the adult because, in addition to bone remodeling, the child undergoes a specific process of endochondral ossification responsible for adequate mineralization of long bones' metaphysis and growth in height. Vitamin D metabolism is known to be deeply involved in these processes. FGF23 might have an influence on bones' growth as well as on the

SUBMITTER: Pons-Belda OD 

PROVIDER: S-EPMC10094813 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature