Signatures of Co-Deregulated Genes and Their Transcriptional Regulators in Kidney Cancers.

ABSTRACT: There are several studies on the deregulated gene expression profiles in kidney cancer, with varying results depending on the tumor histology and other parameters. None of these, however, have identified the networks that the co-deregulated genes (co-DEGs), across different studies, create. Here, we reanalyzed 10 Gene Expression Omnibus (GEO) studies to detect and annotate co-deregulated signatures across different subtypes of kidney cancer or in single-gene perturbation experiments in kidney cancer cells and/or tissue. Using a systems biology approach, we aimed to decipher the networks they form along with their upstream regulators. Differential expression and upstream regulators, including transcription factors [MYC proto-oncogene (MYC), CCAAT enhancer binding protein delta (CEBPD), RELA

SUBMITTER: Ioannou I 

PROVIDER: S-EPMC10094846 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature