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Extracellular Vesicles as Potential Bladder Cancer Biomarkers: Take It or Leave It?

ABSTRACT: Bladder cancer (BC) is the 10th most frequently diagnosed cancer worldwide. Although urine cytology and cystoscopy are current standards for BC diagnosis, both have limited sensitivity to detect low-grade and small tumors. Moreover, effective prognostic biomarkers are lacking. Extracellular vesicles (EVs) are lipidic particles that contain nucleic acids, proteins, and metabolites, which are released by cells into the extracellular space, being crucial effectors in intercellular communication. These particles have emerged as potential tools carrying biomarkers for either diagnosis or prognosis in liquid biopsies namely urine, plasma, and serum. Herein, we review the potential of liquid biopsies EVs' cargo as BC diagnosis and prognosis biomarkers. Additionally, we address the emerging advantages and downsides of using EVs within this framework.

SUBMITTER: Teixeira-Marques A

PROVIDER: S-EPMC10094914 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Extracellular Vesicles as Potential Bladder Cancer Biomarkers: Take It or Leave It?

Teixeira-Marques Ana A Lourenço Catarina C Oliveira Miguel Carlos MC Henrique Rui R Jerónimo Carmen C

International journal of molecular sciences 20230404 7

Bladder cancer (BC) is the 10th most frequently diagnosed cancer worldwide. Although urine cytology and cystoscopy are current standards for BC diagnosis, both have limited sensitivity to detect low-grade and small tumors. Moreover, effective prognostic biomarkers are lacking. Extracellular vesicles (EVs) are lipidic particles that contain nucleic acids, proteins, and metabolites, which are released by cells into the extracellular space, being crucial effectors in intercellular communication. Th ...[more]

PMID: 37047731

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Dataset Information

Extracellular Vesicles as Potential Bladder Cancer Biomarkers: Take It or Leave It?

Publications

Extracellular Vesicles as Potential Bladder Cancer Biomarkers: Take It or Leave It?

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