Computer-Assisted Design of Peptide-Based Radiotracers.

ABSTRACT: In medical imaging, techniques such as magnetic resonance imaging, contrast-enhanced computerized tomography, positron emission tomography (PET), and single-photon emission computed tomography (SPECT) are extensively available and routinely used for disease diagnosis. PET probes with peptide-based targeting are typically composed of small peptides especially developed to have high affinity and specificity for a range of cellular and tissue targets. These probes' key benefits include being less expensive than traditional antibody-based PET tracers and having an effective chemical modification process that allows them to be radiolabeled with almost any radionuclide, making them highly appealing for clinical usage. Currently, as with every pharmaceutical design, the use of in silico strategie

SUBMITTER: Patamia V 

PROVIDER: S-EPMC10095039 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature