Transmembrane Mucin Response in Conjunctival Epithelial Cells Exposed to Wall Shear Stresses.

ABSTRACT: Human conjunctival epithelium cells (HCEC) line the inner surface of the eyelid and cover the sclera and are continuously subjected to wall shear stresses (WSS). The effects of external forces on the conjunctival epithelium are not fully known. The conjunctival epithelium contains stratified squamous cells that synthesize the membrane-spanning mucins MUC1 and MUC16, which play important roles in protecting the ocular surface. Alterations in both gel-forming and membrane-tethered mucins occur in drying ocular surface diseases. The aim of this study was to explore the mechanobiological characteristics of transmembrane mucin secretion and cellular alterations of primary HCEC exposed to airflow-induced WSS perturbations. We exposed the HCEC to a steady WSS of 0.5 dyne/cm² for durati

SUBMITTER: Itah S 

PROVIDER: S-EPMC10095083 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature