Protocol Optimization for Direct Reprogramming of Primary Human Fibroblast into Induced Striatal Neurons.

ABSTRACT: The modeling of neuropathology on induced neurons obtained by cell reprogramming technologies can fill a gap between clinical trials and studies on model organisms for the development of treatment strategies for neurodegenerative diseases. Patient-specific models based on patients' cells play an important role in such studies. There are two ways to obtain induced neuronal cells. One is based on induced pluripotent stem cells. The other is based on direct reprogramming, which allows us to obtain mature neuronal cells from adult somatic cells, such as dermal fibroblasts. Moreover, the latter method makes it possible to better preserve the age-related aspects of neuropathology, which is valuable for diseases that occur with age. However, direct methods of reprogramming have a significant draw

SUBMITTER: Kraskovskaya N 

PROVIDER: S-EPMC10095147 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature