Myokine Musclin Is Critical for Exercise-Induced Cardiac Conditioning.

ABSTRACT: This study investigates the role and mechanisms by which the myokine musclin promotes exercise-induced cardiac conditioning. Exercise is one of the most powerful triggers of cardiac conditioning with proven benefits for healthy and diseased hearts. There is an emerging understanding that muscles produce and secrete myokines, which mediate local and systemic "crosstalk" to promote exercise tolerance and overall health, including cardiac conditioning. The myokine musclin, highly conserved across animal species, has been shown to be upregulated in response to physical activity. However, musclin effects on exercise-induced cardiac conditioning are not established. Following completion of a treadmill exercise protocol, wild type (WT) mice and mice with disruption of the musclin-encoding gene, <

SUBMITTER: Harris MP 

PROVIDER: S-EPMC10095193 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature