Involvement of specific striatal subregion contributes to executive deficits in Alzheimer disease.

ABSTRACT:

Background

There is growing evidence that the striatum plays a central role in cognitive dysfunction. However, it remains unclear whether and how the striatum contributes specifically to executive deficits in Alzheimer disease (AD). We sought to elucidate aberrations in the striatal subregion associated with executive function and its metabolic connectivity with the cortical regions to investigate its role in the pathogenesis of executive deficits in patients with AD.

Methods

Patients with AD and healthy controls underwent a neuropsychological assessment battery, including assessment of executive function, and a hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) scan. We performed voxel-wise analyses of cerebral metabolism between patients and controls,

SUBMITTER: Liu L 

PROVIDER: S-EPMC10095253 | biostudies-literature | 2023 Mar-Apr

REPOSITORIES: biostudies-literature