Gut-brain axis volatile organic compounds derived from breath distinguish between schizophrenia and major depressive disorder.

ABSTRACT:

Background

Signatures from the metabolome and microbiome have already been introduced as candidates for diagnostic and treatment support. The aim of this study was to investigate the utility of volatile organic compounds (VOCs) from the breath for detection of schizophrenia and depression.

Methods

Patients with a diagnosis of major depressive disorder (MDD) or schizophrenia, as well as healthy controls, were recruited to participate. After being clinically assessed and receiving instruction, each participant independently collected breath samples for subsequent examination by proton transfer-reaction mass spectrometry.

Results

The sample consisted of 104 participants: 36 patients with MDD, 34 patients with schizophrenia and 34 healthy controls. Through mixed-model and

SUBMITTER: Henning D 

PROVIDER: S-EPMC10095255 | biostudies-literature | 2023 Mar-Apr

REPOSITORIES: biostudies-literature