Evaluation of the accuracy of the PLCO_m2012 6-year lung cancer risk prediction model among smokers in the CARTaGENE population-based cohort.

ABSTRACT:

Background

The PLCO_m2012 prediction tool for risk of lung cancer has been proposed for a pilot program for lung cancer screening in Quebec, but has not been validated in this population. We sought to validate PLCO_m2012 in a cohort of Quebec residents, and to determine the hypothetical performance of different screening strategies.

Methods

We included smokers without a history of lung cancer from the population-based CARTaGENE cohort. To assess PLCO_m2012 calibration and discrimination, we determined the ratio of expected to observed number of cases, as well as the sensitivity, specificity and positive predictive values of different risk thresholds. To assess the performance of screening strategies if applied between Jan. 1, 1998, and Dec. 31,

SUBMITTER: Jantzen R 

PROVIDER: S-EPMC10095260 | biostudies-literature | 2023 Mar-Apr

REPOSITORIES: biostudies-literature