Novel Insights into circRNA Saga Coming from Spermatozoa and Epididymis of HFD Mice.

ABSTRACT: Obesity is a pathophysiological disorder associated with adiposity accumulation, oxidative stress, and chronic inflammation state that is progressively increasing in younger population worldwide, negatively affecting male reproductive skills. An emerging topic in the field of male reproduction is circRNAs, covalently closed RNA molecules produced by backsplicing, actively involved in a successful spermatogenesis and in establishing high-quality sperm parameters. However, a direct correlation between obesity and impaired circRNA cargo in spermatozoa (SPZ) remains unclear. In the current work, using C57BL6/J male mice fed with a high-fat diet (HFD, 60% fat) as experimental model of oxidative stress, we investigated the impact of HFD on sperm morphology and motility as well as on spermatic ci

SUBMITTER: Manfrevola F 

PROVIDER: S-EPMC10095261 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature