Interstitial Lung Disease and Pulmonary Damage in Primary Sjogren's Syndrome: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Pulmonary lung involvement is the most common extra-glandular manifestation in patients with primary Sjögren's syndrome (pSS), leading to a worsening of the patient's prognosis. To date, different studies have assessed the prevalence of pulmonary involvement and interstitial lung disease (ILD) in pSS patients with different results.

Methods

We performed a systematic literature review and meta-analysis on ILD pooled prevalence in pSS according to the PRISMA and MOOSE guidelines. Furthermore, we explored the pooled prevalence of the two main presentations of pSS-ILD, nonspecific interstitial pneumonia (NSIP) and usual interstitial pneumonia (UIP).

Results

We analysed the pSS-ILD prevalence in 30 studies including 8255 pSS patients. The pSS-ILD pooled prevalen

SUBMITTER: Berardicurti O 

PROVIDER: S-EPMC10095380 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature