Causal Link between Inflammatory Bowel Disease and Fistula: Evidence from Mendelian Randomization Study.

ABSTRACT:

Background

Previous observational studies have found that fistulas are common in Crohn's disease (CD) and less common in ulcerative colitis (UC). However, some patients have a fistula before diagnosis. Based on retrospective analysis, it was not possible to determine whether there was a bi-directional causal relationship between inflammatory bowel disease (IBD) and fistulas.

Methods

Data were extracted from the open GWAS database; 25,042 cases and 34,915 controls were included for IBD, and 6926 cases and 30,228 controls were included for fistula. Two-sample Mendelian randomization and multivariable Mendelian randomization were used in combination to determine the causal relationship between IBD and fistula.

Results

Forward MR showed that IBD increased the risk of colo

SUBMITTER: Tan Z 

PROVIDER: S-EPMC10095427 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature