Δ⁸-THC Protects against Amyloid Beta Toxicity Modulating ER Stress In Vitro: A Transcriptomic Analysis.

ABSTRACT: Alzheimer's disease (AD) represents the most common form of dementia, characterized by amyloid β (Aβ) plaques and neurofibrillary tangles (NFTs). It is characterized by neuroinflammation, the accumulation of misfolded protein, ER stress and neuronal apoptosis. It is of main importance to find new therapeutic strategies because AD prevalence is increasing worldwide. Cannabinoids are arising as promising neuroprotective phytocompounds. In this study, we evaluated the neuroprotective potential of Δ⁸-THC pretreatment in an in vitro model of AD through transcriptomic analysis. We found that Δ⁸-THC pretreatment restored the loss of cell viability in retinoic acid-differentiated neuroblastoma SH-SY5Y cells treated with Aβ_1-42. Moreover, the transcriptomic analysis

SUBMITTER: Gugliandolo A 

PROVIDER: S-EPMC10095455 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature