ZNF750: A Novel Prognostic Biomarker in Metastatic Prostate Cancer.

ABSTRACT: Prostate cancer is the most frequently diagnosed cancer and the fifth leading cause of cancer death among men in 2020. The clinical decision making for prostate cancer patients is based on the stratification of the patients according to both clinical and pathological parameters such as Gleason score and prostate-specific antigen levels. However, these tools still do not adequately predict patient outcome. The aim of this study was to investigate whether ZNF750 could have a role in better stratifying patients, identifying those with a higher risk of metastasis and with the poorest prognosis. The data reported here revealed that ZNF750 protein levels are reduced in human prostate cancer samples, and this reduction is even higher in metastatic samples. Interestingly, nuclear positivity is sig

SUBMITTER: Montanaro M 

PROVIDER: S-EPMC10095592 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature