Preclinical Evaluation of [^155/161Tb]Tb-Crown-TATE-A Novel SPECT Imaging Theranostic Agent Targeting Neuroendocrine Tumours.

ABSTRACT: Terbium radioisotopes (¹⁴⁹Tb, ¹⁵²Tb, ¹⁵⁵Tb, ¹⁶¹Tb) offer a unique class of radionuclides which encompass all four medicinally relevant nuclear decay modalities (α, β⁺, γ, β^-/e^-), and show high potential for the development of element-matched theranostic radiopharmaceuticals. The goal of this study was to design, synthesise, and evaluate the suitability of crown-TATE as a new peptide-conjugate for radiolabelling of [¹⁵⁵Tb]Tb³⁺ and [¹⁶¹Tb]Tb³⁺, and to assess the imaging and pharmacokinetic properties of each radiotracer in tumour-bearing mice. [¹⁵⁵Tb]Tb-crown-TATE and [¹⁶¹Tb]Tb-crown-TATE were prepared efficiently under mild conditions,

SUBMITTER: Wharton L 

PROVIDER: S-EPMC10095901 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature