Metabolic regulation of subcellular sucrose cleavage inferred from quantitative analysis of metabolic functions.

ABSTRACT: Quantitative analysis of experimental metabolic data is frequently challenged by non-intuitive, complex patterns which emerge from regulatory networks. The complex output of metabolic regulation can be summarised by metabolic functions which comprise information about dynamics of metabolite concentrations. In a system of ordinary differential equations, metabolic functions reflect the sum of biochemical reactions which affect a metabolite concentration, and their integration over time reveals metabolite concentrations. Further, derivatives of metabolic functions provide essential information about system dynamics and elasticities. Here, invertase-driven sucrose hydrolysis was simulated in kinetic models on a cellular and subcellular level. Both Jacobian and Hessian matrices of metabolic fu

SUBMITTER: Nagele T 

PROVIDER: S-EPMC10095975 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature