Molecular Diversity of Neuron Types in the Salamander Amygdala and Implications for Amygdalar Evolution.

ABSTRACT: The amygdala is a complex brain structure in the vertebrate telencephalon, essential for regulating social behaviors, emotions, and (social) cognition. In contrast to the vast majority of neuron types described in the many nuclei of the mammalian amygdala, little is known about the neuronal diversity in non-mammals, making reconstruction of its evolution particularly difficult. Here, we characterize glutamatergic neuron types in the amygdala of the urodele amphibian Pleurodeles waltl. Our single-cell RNA sequencing data indicate the existence of at least ten distinct types and subtypes of glutamatergic neurons in the salamander amygdala. These neuron types are molecularly distinct from neurons in the ventral pallium (VP), suggesting that the pallial amygdala and the VP are two separate are

SUBMITTER: Deryckere A 

PROVIDER: S-EPMC10096051 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature