Exploring Antimicrobial Features for New Imidazo[4,5-b]pyridine Derivatives Based on Experimental and Theoretical Study.

ABSTRACT: 5-bromopyridine-2,3-diamine reacted with benzaldehyde to afford the corresponding 6-Bromo-2-phenyl-3H-imidazo[4,5-b]pyridine (1). The reaction of the latter compound (1) with a series of halogenated derivatives under conditions of phase transfer catalysis solid-liquid (CTP) allows the isolation of the expected regioisomers compounds (2-8). The alkylation reaction of (1) gives, each time, two regioisomers, N3 and N4; in the case of ethyl bromoactate, the reaction gives, at the same time, the three N1, N3 and N4 regioisomers. The structures of synthesized compounds were elucidated on the basis of different spectral data (¹H NMR, ¹³C NMR), X-Ray diffraction and theoretical study using the DFT method, and confirmed for each compound. Hirshfeld

SUBMITTER: Hjouji MY 

PROVIDER: S-EPMC10096078 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature