Pirfenidone Protects from UVB-Induced Photodamage in Hairless Mice.

ABSTRACT:

Background

Ultraviolet radiation (UV) is the main environmental factor that causes histological degenerative changes of the skin giving rise to a chronic process called photodamage. Non-melanoma skin cancer induced by UVB radiation is a result of a cascade of molecular events caused by DNA damage in epidermis cells, including persistent inflammation, oxidative stress, and suppression of T cell-mediated immunity. Retinoids such as tretinoin have been widely used in skin to treat photoaging and photodamage, though its secondary adverse effects have been recognized. Pirfenidone (PFD) has emerged as an antifibrogenic, anti-inflammatory and antioxidant agent, and in this work its efficacy was evaluated in a model of UVB-induced photodamage.

Methods

Epidermal, dermal, and inflamma

SUBMITTER: Martinez-Alvarado Y 

PROVIDER: S-EPMC10096127 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature