Characterization and Biological Activities of Four Biotransformation Products of Diosgenin from Rhodococcus erythropolis.

ABSTRACT: Diosgenin (DSG), a steroidal sapogenin derived from the tuberous roots of yam, possesses multiple biological properties. DSG has been widely used as a starting material for the industrial production of steroid drugs. Despite its significant pharmacological activities, moderate potency and low solubility hinder the medicinal application of DSG. Biotransformation is an efficient method to produce valuable derivatives of natural products. In this work, we performed the biotransformation of DSG using five Rhodococcus strains. Compounds 1-4 were isolated and identified from Rhodococcus erythropolis. Compounds 1 and 2 showed potent cytotoxicity against the A549, MCF-7, and HepG2 cell lines. Compounds 3 and 4 are novel entities, and each pos

SUBMITTER: Li Y 

PROVIDER: S-EPMC10096415 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature