Contactin-6-deficient male mice exhibit the abnormal function of the accessory olfactory system and impaired reproductive behavior.

ABSTRACT:

Introduction

Contactin-6 (CNTN6), also known as NB-3, is a neural recognition molecule and a member of the contactin subgroup of the immunoglobulin superfamily. Gene encoding CNTN6 is expressed in many regions of the neural system, including the accessory olfactory bulb (AOB) in mice. We aim to determine the effect of CNTN6 deficiency on the function of the accessory olfactory system (AOS).

Methods

We examined the effect of CNTN6 deficiency on the reproductive behavior of male mice through behavioral experiments such as urine sniffing and mate preference tests. Staining and electron microscopy were used to observe the gross structure and the circuitry activity of the AOS.

Results

Cntn6 is highly expressed in the vomeronasal organ (VNO) and the AOB, and sparsely expres

SUBMITTER: Zhang W 

PROVIDER: S-EPMC10097056 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature