Role of the amygdala-medial orbitofrontal relationship in odor recognition in the elderly.

ABSTRACT:

Introduction

In patients with mild cognitive impairment, pathological changes begin in the amygdala (AMG) and hippocampus (HI), especially in the parahippocampal gyrus and entorhinal cortex (ENT). These areas play an important role in olfactory detection and recognition. It is important to understand how subtle signs of olfactory disability relate to the functions of the above-mentioned regions, as well as the orbitofrontal cortex (OFC). In this study, we evaluated brain activation using functional magnetic resonance imaging (fMRI), performed during the presentation of olfactory stimuli (classified as "normal odors" not inducing memory retrieval), and investigated the relationships of the blood oxygen level-dependent (BOLD) signal with olfactory detection and recognition abilities

SUBMITTER: Sakikawa K 

PROVIDER: S-EPMC10097066 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature