Characteristics of the Gut Microbiome and Serum Metabolome in Patients with Functional Constipation.

ABSTRACT: Functional constipation (FC) is a gastrointestinal disorder with high incidence, and it seriously affects patients' physical and mental health. Several studies have shown that the gut microbiome is associated with FC, but these studies have produced inconsistent findings, with few reflecting the relationship between the gut microbiome and metabolites. This study used 16S rRNA microbial genomics and non-target metabolome based on liquid chromatography-mass spectrometry to analyze the gut microbiota composition and serum metabolic profiles of 30 FC patients and 28 healthy individuals. We found that patients with FC and healthy individuals have different gut microbiota structures and serum metabolic profiles. FC patients had more Bacteroides and butyrate-producing bacteria (Roseburia, Faecali

SUBMITTER: Wang J 

PROVIDER: S-EPMC10097253 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature