The Role of Genetically Engineered Probiotics for Treatment of Inflammatory Bowel Disease: A Systematic Review.

ABSTRACT:

Background

Many preclinical studies have demonstrated the effectiveness of genetically modified probiotics (gm probiotics) in animal models of inflammatory bowel disease (IBD).

Objective

This systematic review was performed to investigate the role of gm probiotics in treating IBD and to clarify the involved mechanisms.

Methods

PubMed, Web of Science, Cochrane Library, and Medline were searched from their inception to 18 September 2022 to identify preclinical and clinical studies exploring the efficacy of gm probiotics in IBD animal models or IBD patients. Two independent researchers extracted data from the included studies, and the data were pooled by the type of study; that is, preclinical or clinical.

Results

Forty-five preclinical studies were included. In t

SUBMITTER: Zhang T 

PROVIDER: S-EPMC10097376 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature