Ontology highlight
ABSTRACT:
SUBMITTER: Watanabe T
PROVIDER: S-EPMC10097392 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Watanabe Takayoshi T Mizuno Hayato Laurence HL Norimatsu Jumpei J Obara Takumi T Cabral Horacio H Tsumoto Kouhei K Nakakido Makoto M Kawauchi Daisuke D Anraku Yasutaka Y
Polymers 20230406 7
Medulloblastoma is a life-threatening disease with poor therapeutic outcomes. In chemotherapy, low drug accumulation has been a cause of these outcomes. Such inadequate response to treatments has been associated with low drug accumulation, particularly with a limited cellular uptake of drugs. Recently, the conjugation of drugs to ligand molecules with high affinity to tumor cells has attracted much attention for enhancing drug internalization into target cells. Moreover, combining tumor-targetin ...[more]