Exploring the role of the outer subventricular zone during cortical folding through a physics-based model.

ABSTRACT: The human brain has a highly complex structure both on the microscopic and on the macroscopic scales. Increasing evidence has suggested the role of mechanical forces for cortical folding - a classical hallmark of the human brain. However, the link between cellular processes at the microscale and mechanical forces at the macroscale remains insufficiently understood. Recent findings suggest that an additional proliferating zone, the outer subventricular zone (OSVZ), is decisive for the particular size and complexity of the human cortex. To better understand how the OSVZ affects cortical folding, we establish a multifield computational model that couples cell proliferation in different zones and migration at the cell scale with growth and cortical folding at the organ scale by combining an ad

SUBMITTER: Zarzor MS 

PROVIDER: S-EPMC10097417 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature