Reassessment of weak parent-of-origin expression bias shows it rarely exists outside of known imprinted regions.

ABSTRACT: In mouse and human, genes subjected to genomic imprinting have been shown to function in development, behavior, and post-natal adaptations. Failure to correctly imprint genes in human is associated with developmental syndromes, adaptive, and metabolic disorders during life as well as numerous forms of cancer. In recent years researchers have turned to RNA-seq technologies applied to reciprocal hybrid strains of mice to identify novel imprinted genes, causing a threefold increase in genes reported as having a parental origin-specific expression bias. The functional relevance of parental origin-specific expression bias is not fully appreciated especially since many are reported with only minimal parental bias (e.g. 51:49). Here, we present an in-depth meta-analysis of previously generated RN

SUBMITTER: Edwards CA 

PROVIDER: S-EPMC10097420 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature