Warm versus cold blood cardioplegia in paediatric congenital heart surgery: a randomized trial.

ABSTRACT:

Objectives

Intermittent cold blood cardioplegia is commonly used in children, whereas intermittent warm blood cardioplegia is widely used in adults. We aimed to compare clinical and biochemical outcomes with these 2 methods.

Methods

A single-centre, randomized controlled trial was conducted to compare the effectiveness of warm (≥34°C) versus cold (4-6°C) antegrade cardioplegia in children. The primary outcome was cardiac troponin T over the 1st 48 postoperative hours. Intensive care teams were blinded to group allocation. Outcomes were compared by intention-to-treat using linear mixed-effects, logistic or Cox regression.

Results

97 participants with median age of 1.2 years were randomized (49 to warm, 48 to cold cardioplegia); 59 participants (61%) had a risk-adjusted

SUBMITTER: Stoica S 

PROVIDER: S-EPMC10097434 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature