Incidence and risk of herpes zoster in patients with ulcerative colitis and Crohn's disease in the USA.

ABSTRACT:

Background

Patients with inflammatory bowel disease (IBD) are at increased risk of herpes zoster (HZ). We evaluated the incidence of HZ in ulcerative colitis (UC) and Crohn's disease (CD) patients and compared this with HZ incidence in a non-IBD population.

Methods

We conducted a retrospective cohort study (GSK study identifier: VEO-000043) of adults aged ≥18 years with UC and CD and without IBD who were identified from claims recorded in a US healthcare database between October 2015 and February 2020. Crude HZ incidence rates/1,000 person-years (PY) were calculated, and comparisons of HZ incidence rates between UC or CD and non-IBD cohorts were made using adjusted generalized linear models.

Results

The study population comprised a total of 29,928 UC, 25,959 CD, and 1

SUBMITTER: Singer D 

PROVIDER: S-EPMC10097435 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature