Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers.

ABSTRACT: Immune-brain interactions influence the pathophysiology of addiction. Lipopolysaccharide (LPS)-induced systemic inflammation produces effects on reward-related brain regions and the dopamine system. We previously showed that LPS amplifies dopamine elevation induced by methylphenidate (MP), compared to placebo (PBO), in eight healthy controls. However, the effects of LPS on the dopamine system of tobacco smokers have not been explored. The goal of Study 1 was to replicate previous findings in an independent cohort of tobacco smokers. The goal of Study 2 was to combine tobacco smokers with the aforementioned eight healthy controls to examine the effect of LPS on dopamine elevation in a heterogenous sample for power and effect size determination. Eight smokers were each scanned with [^11<

SUBMITTER: Zakiniaeiz Y 

PROVIDER: S-EPMC10097458 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature