Neonatal administration of erythropoietin attenuates cognitive deficits in adult rats following placental insufficiency.

ABSTRACT: Preterm birth is a principal cause of neurological disability later in life, including cognitive and behavioral deficits. Notably, cognitive impairment has greater impact on quality of life than physical disability. Survivors of preterm birth commonly have deficits of executive function. Difficulties with tasks and planning complexity correlate positively with increasing disability. To overcome these barriers for children born preterm, preclinical and clinical studies have emphasized the importance of neurorestoration. Erythropoietin (EPO) is a endogenous cytokine with multiple beneficial mechanisms of action following perinatal brain injury. While most preclinical investigations have focused on pathology and molecular mechanisms, translational studies of repair using clinically viable bio

SUBMITTER: Robinson S 

PROVIDER: S-EPMC10097461 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature