Ubiquitin-like conjugation by bacterial cGAS enhances anti-phage defence.

ABSTRACT: cGAS is an evolutionarily conserved enzyme that has a pivotal role in immune defence against infection^1-3. In vertebrate animals, cGAS is activated by DNA to produce cyclic GMP-AMP (cGAMP)^4,5, which leads to the expression of antimicrobial genes^6,7. In bacteria, cyclic dinucleotide (CDN)-based anti-phage signalling systems (CBASS) have been discovered^8-11. These systems are composed of cGAS-like enzymes and various effector proteins that kill bacteria on phage infection, thereby stopping phage spread. Of the CBASS systems reported, approximately 39% contain Cap2 and Cap3, which encode proteins with homology to ubiquitin conjugating (E1/E2) and deconjugating enzymes, respectively^8,12. Although these proteins are required to prevent infe

SUBMITTER: Jenson JM 

PROVIDER: S-EPMC10097602 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature