Predictive Performance of Population Pharmacokinetic Models for Amikacin in Term Neonates.

ABSTRACT:

Background and objective

Amikacin is preferred in treating Gram-negative infections in neonates and it has a narrow therapeutic window. The population pharmacokinetic modeling approach can aid in designing optimal dosage regimens for amikacin in neonates. In this study, we attempted to identify the suitable population pharmacokinetic model from the published reports for the study population from an Indian setting.

Methods

Published population pharmacokinetic studies for amikacin in neonates were identified. Data on structural models and typical pharmacokinetic parameters were extracted from the studies. For the clinical study, neonates who met the inclusion criteria were enrolled in the study from the NICU, Kasturba Medical College, Manipal, during Jan 2020 to March 2022. Dr

SUBMITTER: Matcha S 

PROVIDER: S-EPMC10097735 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature