Embryonic keratin19⁺ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla.

ABSTRACT: The thymus medulla is a key site for immunoregulation and tolerance, and its functional specialisation is achieved through the complexity of medullary thymic epithelial cells (mTEC). While the importance of the medulla for thymus function is clear, the production and maintenance of mTEC diversity remains poorly understood. Here, using ontogenetic and inducible fate-mapping approaches, we identify mTEC-restricted progenitors as a cytokeratin19⁺ (K19⁺) TEC subset that emerges in the embryonic thymus. Importantly, labelling of a single cohort of K19⁺ TEC during embryogenesis sustains the production of multiple mTEC subsets into adulthood, including CCL21⁺ mTEC^lo, Aire⁺ mTEC^hi and thymic tuft cells. We show K19^+<

SUBMITTER: Lucas B 

PROVIDER: S-EPMC10097809 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature