A macropinocytosis-related gene signature predicts the prognosis and immune microenvironment in hepatocellular carcinoma.

ABSTRACT:

Background

Available treatments for hepatocellular carcinoma (HCC), a common human malignancy with a low survival rate, remain unsatisfactory. Macropinocytosis (MPC), a type of endocytosis that involves the non-specific uptake of dissolved molecules, has been shown to contribute to HCC pathology; however, its biological mechanism remains unknown.

Methods

The current study identified 27 macropinocytosis-related genes (MRGs) from 71 candidate genes using bioinformatics. The R software was used to create a prognostic signature model by filtering standardized mRNA expression data from HCC patients and using various methods to verify the reliability of the model and indicate immune activity.

Results

The prognostic signature was constructed using seven MPC-related different

SUBMITTER: Ding X 

PROVIDER: S-EPMC10097907 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature