A maladaptive pleural environment suppresses preexisting anti-tumor activity of pleural infiltrating T cells.

ABSTRACT:

Introduction

Treatment options for patients with malignant pleural effusions (MPE) are limited due, at least in part, to the unique environment of the pleural space, which drives an aggressive tumor state and governs the behavior of infiltrating immune cells. Modulation of the pleural environment may be a necessary step toward the development of effective treatments. We examine immune checkpoint molecule (ICM) expression on pleural T cells, the secretomes of pleural fluid, pleural infiltrating T cells (PIT), and ability to activate PIT ex vivo.

Methods

ICM expression was determined on freshly drained and in vitro activated PIT from breast, lung and renal cell cancer. Secretomics (63 analytes) of activated PIT, primary tumor cultures and MPE fluid was determined

SUBMITTER: Donnenberg VS 

PROVIDER: S-EPMC10097923 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature