Cortico-basal ganglia networks dysfunction associated with disease severity in patients with idiopathic blepharospasm.

ABSTRACT:

Background

Structural changes occur in brain regions involved in cortico-basal ganglia networks in idiopathic blepharospasm (iBSP); whether these changes influence the function connectivity patterns of cortico-basal ganglia networks remains largely unknown. Therefore, we aimed to investigate the global integrative state and organization of functional connections of cortico-basal ganglia networks in patients with iBSP.

Methods

Resting-state functional magnetic resonance imaging data and clinical measurements were acquired from 62 patients with iBSP, 62 patients with hemifacial spasm (HFS), and 62 healthy controls (HCs). Topological parameters and functional connections of cortico-basal ganglia networks were evaluated and compared among the three groups. Correlation analyses w

SUBMITTER: Cheng Q 

PROVIDER: S-EPMC10098005 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature