Pattern of prefrontal cortical activation and network revealed by task-based and resting-state fNIRS in Parkinson's disease's patients with overactive bladder symptoms.

ABSTRACT:

Background

Overactive bladder (OAB) symptoms are common in Parkinson's disease (PD), and negatively contribute to the quality of life (QoL) of patients. To explore the underlying pathophysiological mechanism, we investigated the correlation between the prefrontal cortex (PFC) function and OAB symptoms in PD patients.

Methods

One hundred fifty-five idiopathic PD patients were recruited and classified either as PD-OAB or PD-NOAB candidates based on their corresponding OAB symptom scores (OABSS). A linear regression analysis identified a correlative connection of cognitive domains. Then cortical activation during the performance of the verbal fluency test (VFT) and brain connectivity during resting state were conducted by functional near-infrared spectroscopy (fNIRS) for 10 pat

SUBMITTER: Hou M 

PROVIDER: S-EPMC10098071 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature