Aberrant resting-state brain activity in Huntington's disease: A voxel-based meta-analysis.

ABSTRACT:

Introduction

Functional neuroimaging could provide abundant information of underling pathophysiological mechanisms of the clinical triad including motor, cognitive and psychiatric impairment in Huntington's Disease (HD).

Methods

We performed a voxel-based meta-analysis using anisotropic effect size-signed differential mapping (AES-SDM) method.

Results

6 studies (78 symptomatic HD, 102 premanifest HD and 131 healthy controls) were included in total. Altered resting-state brain activity was primarily detected in the bilateral medial part of superior frontal gyrus, bilateral anterior cingulate/paracingulate gyrus, left insula, left striatum, right cortico-spinal projections area, right inferior temporal gyrus area, right thalamus, right cerebellum and right gyrus rectus

SUBMITTER: Zhang S 

PROVIDER: S-EPMC10098104 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature