Gene expression changes in therapeutic ultrasound-treated venous leg ulcers.

ABSTRACT:

Introduction

Low-frequency, low-intensity ultrasound has been previously shown to promote healing of chronic wounds in humans, but mechanisms behind these effects are poorly understood. The purpose of this study was to evaluate gene expression differences in debrided human venous ulcer tissue from patients treated with low-frequency (20 kHz), low-intensity (100 mW/cm²) ultrasound compared to a sham treatment in an effort to better understand the potential biological mechanisms.

Methods

Debrided venous ulcer tissue was collected from 32 subjects one week after sham treatment or low-frequency, low-intensity ultrasound treatment. Of these samples, 7 samples (3 ultrasound treated and 4 sham treated) yielded sufficient quality total RNA for analysis by ultra-high multi

SUBMITTER: Boerman O 

PROVIDER: S-EPMC10098114 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature