An open-label observational study and meta-analysis of non-invasive vagus nerve stimulation in medically refractory chronic cluster headache.

ABSTRACT:

Background

Many patients with cluster headache (CH) are inadequately controlled by current treatment options. Non-invasive vagus nerve stimulation (nVNS) is reported to be effective in the management of CH though some studies suggest that it is ineffective.

Objective

To assess the safety and efficacy of nVNS in chronic cluster headache (CCH) patients.

Method

We prospectively analysed data from 40 patients with refractory CCH in this open-label, observational study. Patients were seen in tertiary headache clinics at the National Hospital for Neurology and Neurosurgery and trained to use nVNS as preventative therapy. Patients were reivewed at one month and then three-monthly from onset. The primary endpoint was number of patients achieving ≥50% reduction in attack frequ

SUBMITTER: Simmonds L 

PROVIDER: S-EPMC10098146 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature