Mu opioid receptor mRNA overexpression predicts poor prognosis among 18 common solid cancers: A pan-cancer analysis.

ABSTRACT:

Background

Opioids are widely used for patients with solid tumors during surgery and for cancer pain relief. We conducted a pan-cancer genomic analysis to investigate the prognostic features of Mu opioid receptor (MOR) mRNA expression across 18 primary solid cancers.

Methods

All the data of cancer with MOR mRNA were retrieved from cBioPortal for Cancer Genomics. Logistic regression was used to determine the associations between MOR mRNA expression and clinicopathological features. Log-rank test and Cox regression was used for survival analysis. Subgroup analysis and propensity score matching were also carried out.

Results

7,274 patients, including 1,112 patients with positive MOR mRNA expression, were included for data analyses. Positive

SUBMITTER: Sun W 

PROVIDER: S-EPMC10098160 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature