Abnormal focal segments in left uncinate fasciculus in adults with obsessive-compulsive disorder.

ABSTRACT:

Background

Although the specific role of the uncinate fasciculus (UF) in emotional processing in patients with obsessive-compulsive disorder (OCD) has been investigated, the exact focal abnormalities in the UF have not been identified. The aim of the current study was to identify focal abnormalities in the white matter (WM) microstructure of the UF and to determine the associations between clinical features and structural neural substrates.

Methods

In total, 71 drug-naïve patients with OCD and 81 age- and sex-matched healthy controls (HCs) were included. Automated fiber quantification (AFQ), a tract-based quantitative approach, was adopted to measure alterations in diffusion parameters, including fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and

SUBMITTER: Zhang S 

PROVIDER: S-EPMC10098161 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature