INOS expressing macrophages co-localize with nitrotyrosine staining after myocardial infarction in humans.

ABSTRACT:

Introduction

Inducible nitric oxide synthase (iNOS) produces micromolar amounts of nitric oxide (NO) upon the right stimuli, whose further reactions can lead to oxidative stress. In murine models of myocardial infarction (MI), iNOS is known to be expressed in infiltrating macrophages, which at early onset enter the infarcted zone and are associated with inflammation. In contrast cardiac tissue resident macrophages are thought to enhance regeneration of tissue injury and re-establish homeostasis. Both detrimental and beneficial effects of iNOS have been described, still the role of iNOS in MI is not fully understood. Our aim was to examine cell expression patterns of iNOS and nitrotyrosine (NT) production in human MI.

Material and methods

We examined in postmortem human MI he

SUBMITTER: Wilmes V 

PROVIDER: S-EPMC10098457 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature