Best practices in surgical and nonsurgical management of head and neck Merkel cell carcinoma: An update.

ABSTRACT: Merkel cell carcinoma (MCC) is a rare, highly aggressive cutaneous neuroendocrine carcinoma. Controversy exists regarding optimal management of MCC as high-quality randomized studies and clinical trials are limited, and physicians are bound to interpret highly heterogeneous, retrospective literature in their clinical practice. Furthermore, the rising incidence and notably poor prognosis of MCC urges the establishment of best practices for optimal management of the primary tumor and its metastases. Herein, we summarized the relevant evidence and provided an algorithm for decision-making in MCC management based on the latest 2021 National Comprehensive Cancer Network guidelines. Additionally, we report current active MCC clinical trials in the United States. The initial management of MCC is

SUBMITTER: Duarte-Bateman D 

PROVIDER: S-EPMC10098483 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature