Androgen receptor polyQ alleles and COVID-19 severity in men: A replication study.

ABSTRACT:

Background

Ample evidence indicates a sex-related difference in severity of COVID-19, with less favorable outcomes observed in men. Genetic factors have been proposed as candidates to explain this difference. The polyglutamine (polyQ) polymorphism in the androgen receptor gene has been recently described as a genetic biomarker of COVID-19 severity.

Objective

To test the association between the androgen receptor polyQ polymorphism and COVID-19 severity in a large cohort of COVID-19 male patients.

Materials and methods

This study included 1136 male patients infected with SARS-CoV-2 as confirmed by positive PCR. Patients were retrospectively and prospectively enrolled from March to November 2020. Patients were classified according to their severity into three categories:

SUBMITTER: Lopez-Rodriguez R 

PROVIDER: S-EPMC10098487 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature