Imaging of K_Ca 3.1 Channels in Tumor Cells with PET and Small-Molecule Fluorescent Probes.

ABSTRACT: The Ca²⁺ activated K⁺ channel K_Ca 3.1 is overexpressed in several human tumor cell lines, e. g. clear cell renal carcinoma, prostate cancer, non-small cell lung cancer. Highly aggressive cancer cells use this ion channel for key processes of the metastatic cascade such as migration, extravasation and invasion. Therefore, small molecules, which are able to image this K_Ca 3.1 channel in vitro and in vivo represent valuable diagnostic and prognostic tool compounds. The [¹⁸ F]fluoroethyltriazolyl substituted senicapoc was used as positron emission tomography (PET) tracer and showed promising properties for imaging of K_Ca 3.1 channels in lung adenocarcinoma cells in mice. The novel senicapoc BODIPY conjugates with two F-atoms (9 

SUBMITTER: Thale I 

PROVIDER: S-EPMC10098740 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature