Impact of time between faecal immunochemical tests in colorectal cancer screening on screening results: A natural experiment.

ABSTRACT: Repeated rounds of faecal immunochemical testing (FIT) for occult blood is a common method for screening for colorectal cancer (CRC). However, the time interval between FIT rounds is not thoroughly investigated. In a CRC screening trial in South-Eastern Norway, individuals were invited for biennial FIT between 2012 and 2019. The positivity threshold was >15 mcg haemoglobin/g faeces (mcg/g). Due to organizational challenges, the interval between screening rounds randomly varied between 1.5 and 3.5 years, forming a natural experiment. We investigated the detection rate of CRC and advanced neoplasia (AN: CRC or advanced adenoma) at the subsequent round (FIT₂ ), according to the faecal haemoglobin concentration (f-Hb) at the initial screening round (FIT₁ ), and time betwe

SUBMITTER: Ribe SG 

PROVIDER: S-EPMC10098820 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature